Endocrine Abstracts

Introduction: Roux-en-Y gastric bypass (RYGB) places patients at an increased risk of hypocalcemia due to the reduction in calcium absorption (because the procedure bypasses the duodenum and jejunum) and vitamin D deficiency. Subsequent thyroid surgery increases the risk of severe hypocalcemia due to potential post-operative hypoparathyroidism. Only a few cases have been published before of this kind of treatment-challenging hypocalcaemia.Case report: We...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of macro and microvascular disease. Previous studies suggest a link between microvascular and macrovascular complications in diabetes. However, just a few studies have investigated whether the presence of peripheral vascular disease (PVD) is associated with other macrovascular and microvascular complications in diabetes patients. So, this was the aim of our study.Patient...

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...

Introduction: In addition to its well known effects on calcium homeostasis and bone metabolism, growing evidences shows that vitamin D plays an important role in regulation of cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Vitamin D acts through vitamin D receptor (VDR), an intracellular nuclear receptor. It was found an association between different cancer histotypes and single nucleotide polymorphisms (SNPs) of VDR. Despite the close relationship be...

Context: Initial studies reported that RET rearrangements, RAS mutations and BRAF mutation are mutually exclusive genetic events in papillary thyroid carcinoma (PTC). Subsequently, simultaneous occurrence of BRAF mutation and RET/PTC or H4-PTEN has been described in few PTC cases, indicating that these genetic alterations might coexist in PTC in the same cell or in different cells, at least sporadically. In light of the recent finding that frequently BRAF mutation is present o...

Introduction: Thyroid surgery is nowadays associated with low morbidity and extremely low mortality. A consistent association has been observed between high surgical volume and better outcomes. Patients who undergo surgery by a skilled surgeon have fewer complications. On the other hand, different surgical techniques have been associated with different outcomes. Since 1997, thyroid diseases are treated in our department by a multidisciplinary team.Object...

Objective: To evaluate Vitamin D levels and bone metabolism in adult patients with cystic fibrosis (CF).Patients and methods: One hundred patients with CF (53 F, 47 M; age 29±8 years). and 100 healthy controls were enrolled. Patients were assessed through clinical, and laboratory investigations. Evaluation of serum 25 hydroxy vitamin D (25OHD), vertebral fractures (quantitative morphometric analysis) and bone mineral density (BMD) at lumbar spine an...

Introduction: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Initial complete surgical resection is crucial. Recurrence is common and primary cause of mortality is severe hypercalcemia.Clinical case: In 2006, a 51 years old male presented with multiple bone pain, anorexia and weight loss, calcium 11.7 mg/dl, PTH 189 pg/ml. Eight years before a diagnosis of atypical parathyroid adenoma was made after left inferior parathyroidectomy ...

IntroductionGynecomastia is characterized by the abnormal enlargement of one or both male breasts due to proliferation of the glandular tissue, with many possible underlying causes. A documented rare cause of gynecomastia is chest trauma.Case reportWe present a case of a 53-year-old male patient, with a personal history of arterial hypertension and depressive disorder, medicated with fluoxetine, perindopril, ...

Infertility is a growing concern in Western countries. Several factors, including lifestyle habits and increased prevalence of chronic disorders associated with hormonal alterations, increased chronic inflammation and systemic oxidative stress (such as obesity and diabetes mellitus), are contributing to the reduction of reproductive potential among males in modern societies. Evidence suggests these factors negatively impact human sperm quality resulting in a combination of alt...